SINTESIS DAN UJI AKTIVITAS ANTIOKSIDAN SENYAWA 3-(4-METOKSIFENIL)-5-NAFTALEN-1-IL-1-FENIL-4,5-DIHIDRO-PIRAZOL

Authors

  • - Aisyah Laboratorium Kimia Organik Sintesis, Jurusan Kimia, FMIPA Universitas Riau.
  • - Jasril Laboratorium Kimia Organik Sintesis, Jurusan Kimia, FMIPA Universitas Riau.
  • Hilwan Yuda Teruna Laboratorium Kimia Organik Sintesis, Jurusan Kimia, FMIPA Universitas Riau

DOI:

https://doi.org/10.37859/jp.v8i01.520
Keywords: Pyrazoline, microwave irradiation, DPPH and antioxidant.

Abstract

A pyrazoline analog, 3-(4-methoxy-phenyl)-5-naphtalen-1-yl-1-phenyl-4,5-dihydro-pyrazole (PF CA-4OMe) has been synthesized via intermolecular cyclization between substituted chalcones and phenylhydrazine using glacial acetic acid as a catalyst under microwave irradiation. The structure of the compound was characterized based on the interpretation of UV, FTIR, HRMS, 1H-NMR, 13C-NMR, HSQC and HMBC spectra. The antioxidant test was carried out by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result show that PF CA-4OMe was proved to have antioxidant activity with IC50 387,64 µg/mL.

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Published

1930-10-20

How to Cite

Aisyah, .-., Jasril, .-., & Teruna, H. Y. (1930). SINTESIS DAN UJI AKTIVITAS ANTIOKSIDAN SENYAWA 3-(4-METOKSIFENIL)-5-NAFTALEN-1-IL-1-FENIL-4,5-DIHIDRO-PIRAZOL. Photon: Jurnal Sain Dan Kesehatan, 8(01), 1–5. https://doi.org/10.37859/jp.v8i01.520

Issue

Vol. 8 No. 01 (2017): Jurnal Photon

Section

Chemical Sciences

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