Aktivitas Antidiabetes Ekstrak Daun Gaharu (Aquilaria malaccensis Lam) Dan Daun Binahong (Anredera cordifolia) Pada Mencit Jantan
Abstract
The binahong plant (Anredera cordifolia) is known to contain active compounds such as alkaloids, flavonoids, saponins, tannins, and terpenoids that have the potential to lower blood glucose levels. This study aimed to evaluate the antihyperglycemic activity and determine the optimal dose of the combination of ethanol extract of agarwood (Aquilaria malaccensis) leaves and binahong leaves in male mice. The study was conducted experimentally using a Completely Randomized Design (CRD) using 25 mice divided into five treatment groups: a negative control (0.05% NaCMC) and a positive control (metformin). The other three groups were given a combination of agarwood and binahong extracts in dosage ratios of 1:1, 2:1, and 1:2. ANOVA results showed that all extract combinations significantly reduced blood glucose levels compared to the negative control. The 1:1 dose combination showed the best effectiveness, equivalent to metformin, especially on days 3 to 7.
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References
Insana. M. 2021. Asuhan Keperawatan Diabetes Melitus dan Asuhan Keperawatan Stroke. Jakarta: Deepublish.
American Diabetes Association (2010); Diagnosis and Classification of Diabetic Mellitus, USA, America
Hidayat. S., Rodame.M.N. 2015. Kitab Tumbuhan Obat. Jakarta: Penebar Swadaya Grup.
Kusuma, I.Y., Galih, S., Yutia, I.K. 2022. Efek Anti Hiperglikemia Dapaglifozine Monoterapi dan Kombinasi dengan Metformin Pada Mencit. Jurnal Ilmiah Farmako Bahari. Vol 13. No 1. 72-80.
Harahap. M. 2020. Pembuatan The Herbal Dari Daun Gaharu (Aquilaria malaccensi) Dengan Metode Pengeringan Vakum. Skripsi. Universitas Muhammadiyah Sumatera Utara. Medan
Ighodaro, O. M., Akinloye, O. A., & Ajeigbe, K. M. (2017). Alloxan induced toxicity in pancreatic β cells: Selective uptake via GLUT2 and generation of reactive oxygen species. Dalam Metode Pemilihan dan Pembuatan Hewan Model Beberapa Penyakit pada Penelitian Eksperimental (hlm. 58–59)
Rohila, A., dan Ali, S. (2016); Alloxan Induced Diabetes : Mecanism and effects. International Journal of Research in Pharmaceutical and Biomedical Science ; 3 (2):819-820
Rahmani, A.N.S. (2016); Uji efektivitas ekstrak etanol 70% daun ciplukan (Physalis angualata, L) terhadap penurunan kadar glukosa darah pada tikus jantan galur wistar yang diinduksi aloksan, Jurusan Kedokteran UMS.
Raju, P.dan Mamidala, E. (2015); Anti diabetic activity of compound isolated from P. angulata fruits extracts in Alloxsan induce diabetic rats. The Ame J Sci and Med Res; (1) ; 40-43
Sopianti, D.S., Agnes, S. N. dan Tri, Y. 2020. Gambaran Efek Samping Metformin pada Pasien Diabetes Melitus Tipe II. Jurnal Ilmiah Farmacy. 7 (2).
Burhan, A. (2022). Uji Aktivitas Antihiperglikemia Ekstrak Etanol Daun Gaharu (Aquilaria malaccensis Lam.) terhadap Zebrafish (Danio rerio). Jurnal Ilmiah Pharmacy, 9(1), 1–10.
Rollando, M. H., Afthoni, F. Y. C., Cesa, E., & Wibawanty, N. A. (2022). Efektivitas ekstrak etanol daun binahong (Anredera cordifolia) sebagai kandidat antidiabetes pada tikus putih galur Wistar. Jurnal Wiyata, 9(1), 71–78.
Ardinata, I. P. R., Satriyasa, B. K., & Sumardika, I. W. (2024). Uji aktivitas peningkatan fibrogenesis salep ekstrak daun binahong (Anredera scandens (L.) Moq.) 10 % dalam penyembuhan luka diabetes pada tikus galur Sprague Dawley. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 4(1)
Arisandi, A., Fitrianingsih, S. P., & Choesrina, R. (2021, Agustus). Studi Literatur Aktivitas Antidiabetes Beberapa Tanaman Suku Fabaceae. Prosiding Farmasi, 7(2). Universitas Islam Bandung.
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