Analgesic Efficacy Evaluation of Ethanol Extract from African Leaves (Vernonia amygdalina Del.) in Acetic Acid-Induced Mice (Mus musculus)

  • Anom Parmadi Politeknik Kesehatan Bhakti Mulia
  • Sri Rejeki Politeknik Kesehatan Bhakti Mulia
  • Susi Endrawati Politeknik Kesehatan Bhakti Mulia
  • Poppy Julianingrum Politeknik Kesehatan Bhakti Mulia
Keywords: Vernonia amygdalina Del, Analgesic effect, ethanol extract

Abstract

African leaves (Vernonia amygdalina Del.) contain many chemical compounds such as tannins, flavonoids, luteolin, coumarins, phenolic acids, lignans, xanthones, anthraquinones, edotides (peptides). African leaves have anti-parasitic, anti-malarial, anti-helminthic, anti-cancer, anticoagulant, analgesic, antipyretic, anti-inflammatory, antioxidant, antidiabetic effects. Tannins are substances in African leaves (Vernonia amygdalina Del.) which are capable of causing analgesic effects. In this study, ethanol extract of African leaves was made where the treatment in the group of test animals was differentiated into doses of 100 mg/kgBW, 200 mg/kgBW, 400 mg/kgBW with a positive control in the form of aspirin and a negative control in the form of cooking oil. The results showed that the percentage of analgesic power for the positive control was 87.42%, the dose of ethanol extract of African Leaf 100 mg/kgBW = 52.27%, 200 mg/kgBW = 62.29%, and a dose of 400 mg/kgBW = 81.50 %.

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Published
2024-11-30
How to Cite
Parmadi, A., Rejeki, S., Endrawati, S., & Julianingrum, P. (2024). Analgesic Efficacy Evaluation of Ethanol Extract from African Leaves (Vernonia amygdalina Del.) in Acetic Acid-Induced Mice (Mus musculus). Photon: Journal of Natural Sciences and Technology, 15(1). https://doi.org/10.37859/jp.v15i1.4246
Section
Chemical Sciences
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