Sintesis dan Uji Sitotoksik senyawa Klorocalkon (E)-1-(2-klorofenil)-3-(4-metoksifenil)prop-2-en-1-on

  • Hesti Marliza Program Studi Farmasi, STIKes Mitra Bunda Persada


Chalcone is one of the secondary metabolites of flavonoids that can be found in plants. Chalcone compounds both natural and synthetic have been known to show a variety of biological activities such as antibacterial, antifungal, anticancer cytotoxicity, anticolera, anti-inflammatory, antitumor. In the study of the synthesis of chlorochalcone compounds was carried out by the method of scouring using a NaOH catalyst. The results obtained with the composition of chlorokalcon are (E) -1- (2-chlorophenyl) -3- (4-methoxyphenyl) prop-2-en-1-one requested based on melting point data, thin layer chromatography, and HPLC and the composition has been characterized by UV, IR and H-NMR spectroscopy. Cytotoxic activity was carried out using the Brine Shrimps Lethality Test (BSLT) method. The results showed a high cytotoxic chloroclocation activity with an LC50 value of 3.27 μg / ml and this composition was a positive anticancer as evidenced by its cytotoxic properties against Artemia salina Leach larvae with LC50 values ​​<200 μg / ml


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