The Journal Of Pharmacy

Cytotoxic Activity Testing The Extract of Leaves and Yellow Sirsak Fruit (Annona montana) using Method Brine Shrimp Lethality Test (BSLT)

Mon, 30 Jun 2025 00:00:00 +0700

The yellow sirsak plant (Annona montana) is an annonaceae family which has been used by the community as traditional medicine properties such as treating diarrhea, vitamin C deficiency and treating boils. This study aims to determine the cytotoxic activity of the larvae of Artemia salina Leach shrimp by using the BSLT method after giving extracts from the leaves and fruit of yellow sirsak (Annona montana). The results showed that the LC₅₀ value of the n- hexane extract of yellow sirsak leaves was 45,84 µg/mL, the ethyl acetate extract of yellow sirsak leaves was 26,44 µg/mL and the ethanol extract of yellow sirsak leaves was 13,99 µg/mL. The n-hexane extract of yellow sirsak fruit was 31,46 µg/mL, the ethyl acetate extract was 40,45 µg/mL and the ethanol extract of the yellow sirsak fruit was 19,84 µg/mL. The mixture of n-hexane leaves and yellow sirsak fruit was 29,91 µg/mL, the ethyl acetate extract mixture of yellow sirsak leaves and fruit was 21,71 µg/mL and the mixture of ethanol extract and yellow sirsak fruit was 14,75 µg/mL. Based on the research results, it can be concluded that the ethanol extract of yellow sirsak leaves shows the most active cytotoxic activity with an LC₅₀ value of 13,99 µg/mL.

Pengujian Konsentrasi Hambat Minimum Ekstrak Etanol Bunga Telang (Clitoria Ternatea L.) Terhadap Bakteri Klebsiella Pneumoniae

Ayu Rahmawati, Nurbaiti, Nawwar Irfan, Ela Tri Amalia — Mon, 30 Jun 2025 00:00:00 +0700

Penyakit infeksi merupakan salah satu jenis penyakit yang paling umum diderita oleh penduduk di negara berkembang, termasuk Indonesia. Salah satu penyebab bakteri yang menyebabkan infeksi adalah Klebsiella pneumoniae yang menyebabkan infeksi di berbagai tempat, seperti paru-paru, saluran kemih, aliran darah, luka atau tempat pembedahan, pneumonia, meningitis, abses hati, dan endoftalmitis. Bunga telang merupakan tanaman obat yang memiliki segudang manfaat. Ekstraksi tanaman ini bermanfaat untuk mengobati berbagai penyakit dan dapat menghambat pertumbuhan mikroba, seperti Klebsiella pneumoniae. Penelitian ini dilakukan dengan cara eksperimental, menggunakan metode dilusi cair dan dilusi padat. Pengenceran ekstrak etanol bunga telang ditentukan dengan konsentrasi pengujian 1 (4%, 5%, 6%, 7%, 8%, dan 9%), pengujian 2 (11%, 12%, 13%, 14%, dan 15%). Hasil uji konsentrasi hambat minimum (KHM) pada metode dilusi padat terdapat adanya penghambatan pertumbuhan bakteri pada konsentrasi 14%. Hal ini ditunjukkan oleh media yang jernih di sebagian besar permukaan media. Kemudian pada konsentrasi 15% juga menunjukkan adanya penghambatan pertumbuhan koloni bakteri Klebsiella pneumonia. konsentrasi hambat minimum, dilusi, ekstrak etanol bunga telang (Clitoria ternatea L.), Klebsiella pneumoniae.

Hubungan Pengetahuan Dengan Perilaku Dan Rasionalitas Penggunaan Parasetamol Sebagai Upaya Swamedikasi Di Kalangan Ibu Rumah Tangga

Mon, 30 Jun 2025 00:00:00 +0700

The use of over-the-counter drugs such as paracetamol in self-medication is commonly practiced by the public, particularly among housewives. This study aims to determine the correlation between the level of knowledge and the behavior and rationality of paracetamol use in self-medication among housewives in Nagari Sungai Pua. The research employed an observational design with a cross-sectional approach. Samples were selected using purposive sampling, and data were collected through a structured questionnaire. The results showed that the majority of housewives had a good level of knowledge (77.3%), demonstrated positive behavior (63.9%), and used paracetamol rationally (86.6%). Spearman correlation analysis indicated a significant relationship between knowledge and behavior (p < 0.05), as well as between knowledge and the rationality of paracetamol use (p < 0.05). The study concludes that there is a significant correlation between the level of knowledge of housewives and their behavior and rational use of paracetamol in self-medication. It is recommended to enhance public education regarding rational drug use through health professional counseling.

Analisis Kepatuhan terhadap Antiretroviral dan Hubungannya dengan Kualitas Hidup Pasien HIV : Tinjauan Literatur

Pretty Farida Panjaitan, Seftika Sari, Neni Frimayanti — Mon, 30 Jun 2025 00:00:00 +0700

Because it directly affects the level of viral suppression and the patient's quality of life, adherence to antiretroviral (ART) medication is an important component in HIV/AIDS treatment. According to many studies, high ART adherence is correlated with better physical, psychological, and social quality of life. Many factors can affect adherence, including therapy regimen, drug side effects, patient mental condition, and economic and social issues. This study was conducted based on six studies published in scientific journals to evaluate the relationship between HIV patients' quality of life and their adherence to antiretroviral drugs. This review used publications from the last ten years collected from the Publish or Perish and PubMed databases using the keywords adherence, antiretroviral, quality of life, and HIV. Articles that discussed the relationship between ART adherence and HIV patients' quality of life used quantitative or qualitative methods with valid measurement tools. The results showed that patients with an adherence rate of at least 90% had better viral suppression and better quality of life. The main factors that increased adherence were simpler ART regimens, milder side effects, support from health workers, and patient education. ART side effects, mental health problems (such as depression and anxiety), economic issues, and access are issues that hinder adherence

Tingkat Pengetahuan Dan Kepatuhan Penggunaan Antibiotik Pada Masyarakat Di Kelurahan Limbungan Kecamatan Rumbai Timur Kota Pekanbaru

Ayu Rahwamati, Nursyafni Lubis, Putri Tri Adhani, Novtafia Endri — Mon, 30 Jun 2025 00:00:00 +0700

Tingginya penyakit infeksi menjadi salah satu masalah penyakit terbesar dan masuk kedalam sepuluh besar penyakit terbanyak di Indonesia. Berdasarkan data WHO 2015 menyatakan bahwa penyebab kematian pada anak <5 tahun di Indonesia disebabkan oleh penyakit infeksi dengan persentase 1-20 %. Tujuan dari penelitian ini yaitu untuk mengetahui hubungan tingkat pengetahuan dan kepatuhan antibiotik pada masyarakat di Kelurahan Limbungan Kecamatan Rumbai Timur Kota Pekanbaru. Penelitian menggunakan menggunakan metode survey cross- sectional dan jenis penelitian ini adalah kuantitatif. Sampel penelitian ini menggunakan 100 responden dengan instrumen penelitian menggunakan kuesioner. Analisa data penelitian yang dilakukan antara lain analisa univariat, bivariat dengan metode uji Chi-square. Hasil penelitian menunjukkan terdapat hubungan signifikan antara tingkat pengetahuan dengan kepatuhan dalam penggunaan obat antibiotik.

Aktivitas Antidiabetes Ekstrak Daun Gaharu (Aquilaria malaccensis Lam) Dan Daun Binahong (Anredera cordifolia) Pada Mencit Jantan

Mon, 30 Jun 2025 00:00:00 +0700

The binahong plant (Anredera cordifolia) is known to contain active compounds such as alkaloids, flavonoids, saponins, tannins, and terpenoids that have the potential to lower blood glucose levels. This study aimed to evaluate the antihyperglycemic activity and determine the optimal dose of the combination of ethanol extract of agarwood (Aquilaria malaccensis) leaves and binahong leaves in male mice. The study was conducted experimentally using a Completely Randomized Design (CRD) using 25 mice divided into five treatment groups: a negative control (0.05% NaCMC) and a positive control (metformin). The other three groups were given a combination of agarwood and binahong extracts in dosage ratios of 1:1, 2:1, and 1:2. ANOVA results showed that all extract combinations significantly reduced blood glucose levels compared to the negative control. The 1:1 dose combination showed the best effectiveness, equivalent to metformin, especially on days 3 to 7.

Tingkat Kepatuhan Minum Obat Dan Sikap Pasien Diabetes Mellitus Di Klinik Utama Bersama Pasir Pengaraian Rokan Hulu

Mon, 30 Jun 2025 00:00:00 +0700

Kesehatan yang baik muncul dari tingkat kepatuhan seseorang dalam mengkonsumsi obat. Kepatuhan seorang pasien dalam mengkonsumsi obat memiliki pengaruh besar terhadap kesembuhan pasien. Kepatuhan pasien minum obat antidiabetik sangat menentukan keberhasilan pasien dalam pengobatan diabetes mellitus. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepatuhan minum obat dan sikap pasien terhadap penyakit diabetes mellitus di Klinik Utama Bersama Pasir Pengaraian Rokan Hulu Riau. Metode penelitian bersifat deskriptif dengan menggunakan kuesioner sebagai tolak ukur kepatuhan pada pasien diabetes mellitus. Hasil penelitian menunjukkan tingkat kepatuhan minum obat pada pasien level tinggi sebanyak 7 orang (22,6%), level sedang 5 orang (16,1%) dan level rendah 19 orang (61,3%). Tingkat sikap responden terhadap pengobatan diabetes mellitus sebanyak 13 responden (42%) baik dan 18 responden (58%) kurang baik. Berdasarkan hasil penelitian menunjukan bahwa tingkat kepatuhan minum obat dan sikap pasien terhadap pengobatan diabetes mellitus di Klinik Utama Bersama Pasir Pengaraian Rokan Hulu Riau masih rendah dan kurang baik.

Metode Menurunkan Angka Medication Error Pada Tahap Dispensing Di Instalasi Farmasi Rumah Sakit: Artikel Review

Dilla Wahyuni, Seftika Sari, Neni Frimayanti — Mon, 30 Jun 2025 00:00:00 +0700

Mengurangi angka kejadian kesalahan pengobatan (medication error) pada tahap dispensing di instalasi farmasi rumah sakit adalah salah satu tantangan yang besar dalam pelayanan kesehatan. Kesalahan ini bisa terjadi akibat berbagai faktor, seperti kesalahan dalam penulisan resep dan komunikasi yang kurang efektif. Untuk meminimalkan risiko tersebut, berbagai metode telah diterapkan, termasuk sistem verifikasi ganda (double check), peningkatan komunikasi antara apoteker dan dokter, serta penerapan teknologi dan sistem otomatisasi. Selain itu, pelatihan berkelanjutan bagi staf farmasi dan pengembangan budaya keselamatan sangat diperlukan untuk mendukung upaya ini. Meskipun terdapat beberapa kendala dalam penerapan metode tersebut, seperti biaya teknologi yang tinggi dan kepatuhan staf, pendekatan yang komprehensif dan berkelanjutan diharapkan mampu secara signifikan menurunkan angka kesalahan pengobatan. Dengan demikian, keselamatan pasien dan kualitas pelayanan kesehatan dapat meningkat secara menyeluruh

Analisis Prediksi Potensi Farmakokinetik Dan Toksisitas Pada Senyawa Kurkumin Dari Extrak Curcuma Aromatica Secara In Silico

Anjas Wilapangga, Muhammad Arif — Mon, 30 Jun 2025 00:00:00 +0700

Curcuma aromatica Salisb., commonly known as wild turmeric, is a species from the Zingiberaceae family rich in curcuminoid compounds. Curcumin, its main active compound, possesses various therapeutic potentials, including anti-inflammatory, anti-allergic, antioxidant, and antimicrobial properties, as well as roles in the treatment of cancer and HIV. This study aimed to predict the ADMET profile of curcumin extracted from C. aromatica Salisb. using in silico methods. The prediction results indicate that curcumin exhibits good intestinal absorption and does not show mutagenic, hepatotoxic, skin irritant, or systemic toxic properties at reasonable doses. Furthermore, curcumin does not interact dangerously with the CYP2D6 enzyme. Overall, the ADMET profile suggests that curcumin is relatively safe for use as a drug active ingredient. Despite its safety, this study also identified a major challenge related to curcumin's low bioavailability, which is caused by its poor water solubility and limited distribution. This low distribution can restrict its therapeutic effectiveness in target tissues. This challenge poses a risk of accumulation if high doses are administered continuously. Therefore, special formulations, such as nanoparticles, are highly necessary to enhance the solubility, distribution, and therapeutic efficacy of curcumin in the future.