Analisis Prediksi Potensi Farmakokinetik Dan Toksisitas Pada Senyawa Kurkumin Dari Extrak Curcuma Aromatica Secara In Silico
Abstract
Curcuma aromatica Salisb., commonly known as wild turmeric, is a species from the Zingiberaceae family rich in curcuminoid compounds. Curcumin, its main active compound, possesses various therapeutic potentials, including anti-inflammatory, anti-allergic, antioxidant, and antimicrobial properties, as well as roles in the treatment of cancer and HIV. This study aimed to predict the ADMET profile of curcumin extracted from C. aromatica Salisb. using in silico methods. The prediction results indicate that curcumin exhibits good intestinal absorption and does not show mutagenic, hepatotoxic, skin irritant, or systemic toxic properties at reasonable doses. Furthermore, curcumin does not interact dangerously with the CYP2D6 enzyme. Overall, the ADMET profile suggests that curcumin is relatively safe for use as a drug active ingredient. Despite its safety, this study also identified a major challenge related to curcumin's low bioavailability, which is caused by its poor water solubility and limited distribution. This low distribution can restrict its therapeutic effectiveness in target tissues. This challenge poses a risk of accumulation if high doses are administered continuously. Therefore, special formulations, such as nanoparticles, are highly necessary to enhance the solubility, distribution, and therapeutic efficacy of curcumin in the future.
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