SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN 3,5 BIS((E)-METOKSI BENZILIDEN)-1-(2-ETIL ASETAT)-PIPERIDIN-4-ON

  • Siti Aisyah Fakultas Matematika dan Ilmu Pengetahuan Alam Kampus Binawidya Pekanbaru, 28293, Indonesia
  • Adel Zamri Fakultas Matematika dan Ilmu Pengetahuan Alam Kampus Binawidya, Pekanbaru, 28293, Indonesia
  • Hilwan Yuda Teruna Fakultas Matematika dan Ilmu Pengetahuan Alam Kampus Binawidya, Pekanbaru, 28293, Indonesia
Keywords: 4-piperidone, Methoxybenzaldehyde, toxicity, BSLT.

Abstract

Curcumin analogs are secondary metabolites and belong to the phenolic group. These compounds have biological activities, such as anti-inflammatory, anticancer and antioxidant. This studies has successfully synthesized 3,5-bis ((E)-metoxy benzylidene) -1-(- 2-ethyl acetate) piperidine 4-one analog compound from 4-piperidone with 4-methoxy benzaldehyde by using reflux method. Compounds obtained in the form of yellow solids with yield 83.01%. The melting point was measured, identified by TLC then elucidated with UV-Vis, FT-IR, LC-MS, 1H NMR obtained results showed that the curcumin compound had a structure in accordance with the target molecule. The toxicity test using the BSLT method showed that the two compounds had LC50 values = 1.061μg / mL.

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Published
2018-10-28
How to Cite
Aisyah, S., Zamri, A., & Teruna, H. Y. (2018). SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN 3,5 BIS((E)-METOKSI BENZILIDEN)-1-(2-ETIL ASETAT)-PIPERIDIN-4-ON. Photon: Jurnal Sain Dan Kesehatan, 9(1), 159-163. https://doi.org/10.37859/jp.v9i1.1075
Section
Chemistry Sciences
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