SINTESIS SENYAWA MANNICH-EUGENOL SEBAGAI ANTIMIKROBA BARU DALAM MENGATASI RESISTENSI ANTIMIKROBA

  • Anisa Aulia Rahim Jurusan Kimia, FMIPA, Universitas Muhammadiyah Riau
  • Roma Dhony Jurusan Kimia, FMIPA, Universitas Muhammadiyah Riau
  • Shinta Okka Zulya Jurusan Biologi, FMIPA, Universitas Muhammadiyah Riau
  • Jufrizal Syahri Jurusan Kimia, FMIPA, Universitas Muhammadiyah Riau

Abstract

Anti-microbial resistance is one of the biggest health challenges in the world. In 2015, WHO reported at least around 700 thousand people died due to anti-microbial resistance. One of the many natural compounds found in Indonesia and reported to have anti-microbial activity is the eugenol compound. However, the activity of the resulting compound is still very weak, so it is necessary to modify the functional group to increase its anti-microbial activity by adding an amine group. In this research, a Mannich-eugenol compound was synthesized based on Docking and experimental studies. Molecular docking method using Discovery studio software was performed to Methicillin-Resistant Staphylococcus aureus Sar2676 (2X3F.pdb.) To understand the interactions formed by compound structure was confirmed by spectrophotometric analysis using MS, H- and CNMR. Eugenol without the addition of an amine group to the S. aureus bacteria showed a zone of 12.2 mm and the addition of morpholine and dimethylamine could significantly increase the antibacterial activity to 15.2 mm and 18.6 mm respectively while eugenol without the addition of an amine group to the bacteria E. coli shows a zone of 11.5 mm and the addition of morpholine and dimethylamine can significantly increase the antibacterial activity respectively to 14.3 mm and 20 mm. Molecular docking of the compound shows the interaction of strong hydrogen bonds with SER186, ARG188, ASP151, HIS35, LYS150, LYS185, PHE147, with an interaction energy of CDOCKER -48.84 kcal / mol

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Published
2019-10-21
Abstract views: 54 , pdf (Bahasa Indonesia) downloads: 0